ATRX subfamily
The ATRX subfamily derives its name from the Alpha Thalassemia/Mental Retardation syndrome, X linked genetic disorder caused by defects in the activity of the human member, ATRX 1. This protein is localised to centromeric heterochromatin 2, and purified complexes have been shown to increase the accessibility of nucleosomal DNA although with only moderate efficiency 3. ATRX has been implicated both in the regulation of transcription and heterochromatin structure 4, although the mechanism by which it acts is unclear.
subfamily members
names associated with subfamily members
XH2, XNP, Hp1bp2
subfamily sequence logo

Generated using weblogo from alignment of identified
subfamily members for columns where at least 90% of
sequences have residues. Distances between features
may be truncated.
references
1: Gibbons, R. J., D. J.
Picketts, et al. (1995). Mutations in a putative
global transcriptional regulator cause X-linked
mental retardation with alpha-thalassemia (ATR-X
syndrome). Cell 80(6): 837-45. PubMed
2: McDowell, T. L., R. J.
Gibbons, et al. (1999). Localization of a
putative transcriptional regulator (ATRX) at
pericentromeric heterochromatin and the short
arms of acrocentric chromosomes. Proc Natl Acad
Sci U S A 96(24): 13983-8. PubMed